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ORIGINAL ARTICLE
Year : 2016  |  Volume : 25  |  Issue : 1  |  Page : 60-69

Blood pressure indices and disease severity in patients with sickle cell anaemia


1 Department of Haematology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State; Department of Haematology, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State, Nigeria
2 Chemical Pathology, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State, Nigeria
3 Department of Haematology, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State; State Specialist Hospital, Ondo, Ondo State, Nigeria
4 Department of Haematology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria
5 Department of Medical laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria
6 Department of Haematology, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State, Nigeria

Correspondence Address:
C Aneke John
Department of Haematology, Nnamdi Azikiwe University Teaching Hospital, PMB, 5025, Nnewi,Anambra State
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1115-2613.278255

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BACKGROUND: Individuals with sickle cell anaemia (SCA) have lower systemic blood pressures compared to individuals with haemoglobin Hb AA phenotype. OBJECTIVE: To evaluate blood pressure indices of individuals with SCA in steady state, in comparison with haematological and clinical markers of disease severity. METHODOLOGY: Seventy-nine (79) individuals with SCA (subjects) in steady state and 50 age-matched individuals with Hb AA (controls) were prospectively studied. Height, blood pressure (BP), weight, creatinine clearance (by 24-hour urine collection), full blood count (FBC) and reticulocyte count were obtained from all subjects and controls. Body mass index (BMI), corrected reticulocyte count, mean arterial pressure (MAP) and pulse pressure (PP) were calculated using standard protocols. The frequency of vaso-occlusive crises in the last one year and number of blood transfusions in the last two years were obtained from subjects. Data was analyzed using descriptive and inferential statistics and p ≤0.05 was used to define the level of statistical significance. RESULTS: The systolic (105.52±11.75mmHg and 113.20±7.94mmHg respectively; P = 0.01), diastolic (62.59±9.33mmHg and 75.40±5.70mmHg respectively; P=0.03) and mean arterial pressures (76.90±8.81mmHg and 88.00±5.51mmHg respectively;P =0.04) were significantly lower in subjects when compared with controls. ; pulse pressure (PP) was however significantly higher in subjects than controls (42.92±10.91mmHg and37.80±7.43mmHg respectively (P = 0.03). In female subjects, the white cell count was negatively correlated with systolic BP (r = -0.39;P = 0.01) and PP (r = -0.33; P = 0.03). CONCLUSION: Lower systolic and pulse pressures may predict worsening disease severity in individuals with sickle cell anaemia.


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