• Users Online: 224
  • Print this page
  • Email this page
Year : 2020  |  Volume : 29  |  Issue : 3  |  Page : 415-421

Comparative pre- and post-treatment effects of Nigella sativa oil on lipid profile and antioxidant enzymes in a rat model of diabetes mellitus

1 Department of Pharmacology, Therapeutics and Toxicology, College of Medicine of the University of Lagos, Lagos, Nigeria
2 Department of Physiology, College of Medicine of the University of Lagos, Lagos, Nigeria
3 Department of Pharmacology and Therapeutics, Usmanu Danfodiyo University, Sokoto, Nigeria
4 Department of Internal Medicine, Federal Medical Centre, Lagos, Nigeria

Correspondence Address:
Dr. Abdullahi A. Adejare
Department of Physiology, College of Medicine of the University of Lagos, Lagos
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/NJM.NJM_42_20

Rights and Permissions

Background: Lipid profile dysregulation and oxidative stress are important risk factors for cardiovascular disease in diabetic individuals. Nigella Sativa (NS) oil has been reported to have a favorable effect on triglycerides (TG) in rat models of diabetes mellitus. There is a dearth of information available about preventive or corrective use to manage and ameliorate diabetes. Aim: This study sought to ascertain the comparative pre and post-treatment effects of the oil on TG, cholesterol, high-density lipoprotein (HDL), low-density lipoprotein, and key antioxidant enzymes levels in diabetic rats. Methods: Thirty (30) Wistar rats were divided into 6 groups of 5 rats each as follows: Group I rats took normal chow ad libitum and served as Control. Group II rats were induced with diabetes using streptozocin (50 mg/Kg BW). Group III and IV rats were pre-administered with 0.5 and 1 ml of the oil, respectively, before induction, whereas Group V and VI rats were treated with 0.5 and 1 ml of the oil after induction. The listed parameters were assessed in the plasma at the end of the study. Results: Diabetes induction caused a significant increase in the TG level. There was no significant change in the oxidative stress parameters. Only post-administration caused a significant reduction in TG level, whereas both pre and post-administrations caused a significant improvement in HDL levels. Both pre- and post-administrations caused an increase in superoxide dismutase and catalase levels when causing a significant reduction in malondialdehyde level. Conclusion: Post-induction treatment may be more effective in the correction of lipid dysregulation and oxidative stress in diabetes.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded4    
    Comments [Add]    

Recommend this journal