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 Table of Contents  
ORIGINAL ARTICLE
Year : 2020  |  Volume : 29  |  Issue : 3  |  Page : 486-490

Determinants of outcome in febrile children admitted into the emergency rooms of two tertiary hospitals in Enugu Southeast Nigeria


1 Department of Paediatrics, College of Medicine, University of Nigeria, Ituku-Ozalla, Enugu, Nigeria
2 Department of Paediatrics, College of Medicine, Enugu State University of Science and Technology, Enugu, Nigeria

Date of Submission09-Jun-2020
Date of Decision24-Jun-2020
Date of Acceptance11-Jul-2020
Date of Web Publication18-Sep-2020

Correspondence Address:
Dr. Benedict O. Edelu
Department of Paediatrics, College of Medicine, University of Nigeria, Ituku-Ozalla, Enugu
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/NJM.NJM_101_20

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  Abstract 


Introduction: Febrile illnesses have continued to be the highest causes of mortalities in children admitted to the children emergency rooms in Nigeria. This study was carried out to review the determinants of outcome in children admitted for febrile illness into the emergency rooms of two tertiary institutions in Enugu, Nigeria. Materials and Methods: This was a retrospective study of 335 children who presented with fever to the emergency rooms over one year (January–December 2018). Their case records were retrieved, and the necessary information was obtained using a structured questionnaire. Statistical analysis included odds ratio and Chi-square test. Results: The mean age of the children was 43.20 ± 50.30 months. The mean temperature at presentation was 38.2°C ± 0.9°C. Fever of 39.0°C or above at presentation and fever duration of >2 days were significantly associated with fatal outcome. Children residing in rural areas or referred from other health facilities were more likely to die. The risk of dying from fever was highest when it was associated with diarrhea, weakness, pallor, convulsions, unconsciousness, and difficult/fast breathing. Conclusion: Most of the factors responsible for mortality in febrile children are largely preventable and treatable when the presentation is early.

Keywords: Determinants, emergency room, febrile children, Nigeria, outcome


How to cite this article:
Igbokwe OO, Iloh ON, Edelu BO, Nduagubam OC, Ndu IK. Determinants of outcome in febrile children admitted into the emergency rooms of two tertiary hospitals in Enugu Southeast Nigeria. Niger J Med 2020;29:486-90

How to cite this URL:
Igbokwe OO, Iloh ON, Edelu BO, Nduagubam OC, Ndu IK. Determinants of outcome in febrile children admitted into the emergency rooms of two tertiary hospitals in Enugu Southeast Nigeria. Niger J Med [serial online] 2020 [cited 2020 Oct 24];29:486-90. Available from: http://www.njmonline.org/text.asp?2020/29/3/486/295276




  Introduction Top


Fever is one of the most common presenting features of illness in pediatric practice, especially in children under the age of five years. In both developed and developing countries, febrile illnesses are probably the most common reason for presentation to the pediatric emergency department.[1],[2],[3]

Fever is an elevation of body temperature above normal and is an adaptive response by the body. Fever can be beneficial because it retards the growth and reproduction of infective organisms in the body, enhances neutrophil production and T-lymphocyte proliferation, and also aids in the acute-phase reaction.[4],[5] The degree of fever may not always correlate with the severity of illness, and in some cases, severely ill children may present with hypothermia rather than fever.[4]

Fever in children is associated with a high level of anxiety among caregivers who often resort to the use of antipyretic and other medications, often at inappropriate doses prior to presentation at the health facilities.[6],[7] This anxiety has also led to the use of the term “fever phobia” by some researchers.[6],[7]

Most febrile illnesses are a result of infectious diseases, of which malaria accounts for over 50% in our environment.[8] Febrile illnesses such as malaria, sepsis, meningitis, pneumonia, and acute gastroenteritis are the highest causes of mortalities in children admitted to the emergency rooms of Nigerian hospitals.[2],[3],[9],[10] This pattern of mortality seems to have remained constant over the years despite the progress made in technology and workforce in dealing with these diseases.[2],[11]

This study was conducted to determine the factors that influence the outcome in children admitted for febrile illnesses in the two tertiary institutions in Enugu, Southeast Nigeria.


  Materials and Methods Top


This retrospective study was carried out over a 12-month period (January–December 2018), during which case records of febrile children who presented to the children emergency rooms of the two tertiary hospitals in Enugu (Enugu State University Teaching Hospital and the University of Nigeria Teaching Hospital [UNTH]), Southeast Nigeria, were obtained. Both the hospitals receive cases from all over the state as well as nearby communities in the neighboring states. Ethical approval was obtained from the UNTH's research and ethics committee prior to commencement of the study.

The admission register was used to identify all the children who presented with fever within the period of study. Their case records were retrieved, and the necessary information was obtained using a structured questionnaire. The information included biodata, presenting symptoms, relevant history, examination findings, results of laboratory investigations conducted, diagnoses, and outcomes (discharged, transferred, or died). The inclusion criteria were all children admitted for at least 24 h with fever as a presenting complaint, either alone or with other symptoms. Those with incomplete case records were excluded from the analysis. Data were entered and analyzed using the Statistical Package for Social Sciences (SPSS) version 20 (Chicago, IL, USA). The analysis was mainly descriptive. Continuous variables were expressed as mean ± standard deviation. The relationship between variables was tested for significance using Pearson's Chi-square or Fisher's exact test. P < 0.05 was regarded as significant (two-tailed test). The association between variables (such as age, residence, height, and duration of fever, associated clinical features and prior treatment) and outcome was measured using the odds ratio. The results were presented as percentages and proportions in forms of prose and tables.


  Results Top


A total of 1405 children presented to the two emergency rooms within the period of study, of which 982 (69.9%) were admitted. Of the admitted cases, a total of 335 cases fulfilled the inclusion criteria. There were 197 males, with a male-to-female ratio of 1.4:1. Their ages ranged from 1 month to 205 months (17 years), with a mean age of 43.20 ± 50.30 months and a median age of 19 months. A total of 253 (75.5%) children were under the age of 60 months (5 years). Most of the study subjects (224) resided in urban and semi-urban areas, while the others (111) resided in rural areas. The age and sex distributions are as shown in [Table 1].
Table 1: Age and sex distribution of the patients

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Fever duration prior to presentation ranged from a few hours to 21 days, with a mean of 3.95 ± 3.54 days. Fever duration of >2 days prior to presentation was significantly associated with death (P = 0.03 χ2 = 4.57).

The axillary temperature at presentation ranged from 36.2°C to 42°C, with a mean of 38.2°C ± 0.9°C. Fifty-six (17%) did not have a fever (≥37.6°C) at presentation. A total of 301 children (89.9%) had received an antipyretic prior to presentation, with the most common antipyretic being paracetamol (269, 89.4%). Sixteen (5.3%) received nonsteroidal anti-inflammatory drugs (NSAID) such as Ibuprofen, while 13 (4.3%) used a combination of paracetamol and NSAID. In addition to the antipyretic, 201 (60%) had received some form of treatment before presentation, mostly antimalarials alone (47, 23.7%), antibiotics alone (50, 24.9%), and a combination of both (45, 22.4%). Other medications taken prior to presentation included cough syrups, hematinic, and multivitamins (14, 7%). The rest (45, 22.4%) did not know the names of drugs administered. Only 33 subjects (9.9%) were referred from other health facilities.

None of the study participants presented with fever alone. The associated symptoms included vomiting (42.2%), diarrhea (31.1%), and cough (33.4%). Other clinical features include tachycardia (66.3%), tachypnea (45.4%), and hepatomegaly (29.3%). The risk of dying from fever was higher when it was associated with diarrhea, weakness, pallor, convulsions, loss of consciousness, and difficult/fast breathing [Table 2].
Table 2: Outcome based on major clinical features associated with fever

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The common investigations carried out for these subjects to aid the diagnoses included malaria rapid diagnostic test/malaria microscopy, full blood count, random blood glucose, and urinalysis.

[Table 3] shows the diagnoses made in these febrile children. The most common diagnoses were malaria and sepsis/bacteremia, which constituted about 52% of all the cases. Meningitis, sepsis, and typhoid fever, however, had the highest case fatality rates.
Table 3: Diagnosis made in the febrile children and outcome

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There were a total of 42 deaths (12.5% mortality) and 7 were discharged against medical advice. The rest were either discharged home or transferred to the ward after stabilization in the emergency room.

[Table 4] shows the relationship between various variables and outcomes. There was no statistically significant difference in the proportion of deaths between children under 5 years and those above 5 years, P = 0.38, χ2 = 0.77. However, residence in rural areas had more significant mortality when compared to urban and semi-urban areas (P = 0.01, χ2 = 9.53). Significant factors associated with increased mortality included referral from other health facilities (χ2 = 7.25, P = 0.01) and treatment before presentation to the emergency department (χ2 = 0.01, P = 6.90). Also, the presence of neutrophilia increases the risk of mortality (χ2 = 11.96, P = 0.00). Of the 106 children who had anemia, only 55 (51.9%) were severe enough to be transfused with blood. There was a significant association between blood transfusion and death in the children (P = 0.00, χ2 = 16.44).
Table 4: Relationship between tested variables and outcomes

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  Discussion Top


Late presentation to health facilities has always been one of the factors that lead to negative health outcomes and poor prognosis.[7],[9],[12],[13] In this study, the mean duration of fever prior to presentation to the emergency department was four days. Children who had a fever for >48 h before presentation were at higher risk of death than those who presented earlier. A number of them had visited other lower cadre health-care facilities or patent medicine vendors prior to presentation to the emergency room. Some lower and private health-care providers may delay in referring to other centers, probably as a result of inexperience or financial gains. In the current study, referral from other health-care facilities was associated with more deaths when compared to patients that came straight on their own. This may not be unconnected to worsening and complications of the disease as a result of failure to initiate the appropriate treatment early. Adequate, early treatment is an important predictor of outcome in infectious diseases.[14]

Febrile children presenting from the rural areas were more likely to have a poorer outcome when compared to those in urban areas. An earlier study in Southeast Nigeria found that caregivers in rural arrears were more likely to patronize patent medicine dealers, herbal practitioners, and use leftover medications before seeking care in health facilities when the illness worsens. This is compounded by logistics problems (finance and transportation) that impede on early presentation to the health facilities.[15]

Most of the children in this study received antipyretics before the presentation, the most common being paracetamol. Similarly, Pillar and Herzogin, Switzerland, observed a high use of antipyretics before a visit to the emergency department.[16] Although fever may be a beneficial response in infections,[4],[5] high fever at presentation (>39.0°C) was associated with increased mortality in our study. Some authors[4],[5] believe that the severity of the fever does not always correlate with the severity of illness, whereas other authors[17],[18] have found a direct correlation between temperature and severity of the infection. In addition, the use of paracetamol for fever relief has been found to prolong fever clearance time in malaria.[19]

Self-medication and patronage of patent medicine vendors are very common practices in our environment.[15] They are often associated with inappropriate administration of medications, which can lead to worsening of the disease process and delayed presentation to the health facility, leading to increased morbidity and mortality, as found in previous studies.[9],[12]

Neutrophilia is often an indication of an ongoing acute infection. Moreover, in the current study, it was one of the determinants of poor outcome. It thus calls for early and appropriate use of antimicrobials when managing febrile children in the emergency room, even in the absence of a culture result.

Similar to what has been reported in earlier studies, the need for blood transfusion as a result of severe anemia was associated with increased mortality.[20] Severe anemia in children, which could be a consequence of severe malaria or sepsis, can progress to anemic heart failure with attendant hemodynamic compromise, and can lead to death if not addressed urgently. Timely blood transfusion might in fact save lives.[21] However, the challenges of urgent blood transfusion in our environment may further worsen the prognosis for such children in dire need of blood transfusion.

All the children had other presenting symptoms in addition to the fever. The additional symptoms that posed a greater risk of death when associated with fever included diarrhea, weakness, pallor, convulsions, unconsciousness, and difficult/fast breathing. These symptoms are also regarded as severe features in the World Health Organization's Integrated Management of Childhood Illnesses;[22] it is therefore expected that any febrile child presenting with any of these symptoms should receive prompt attention.

Although malaria had the highest frequency of presentation in our study, sepsis, meningitis, and typhoid fever had the highest case fatality rates and thus poorer prognoses. This is similar to the mortality pattern in other Nigerian studies.[2],[3],[9],[10] Pharyngotonsillitis had the best prognosis among the common febrile illnesses identified in the current study. This could be due to ready response to appropriate antibiotic therapy in the eradication of the bacterial organisms once the diagnosis, which is often clinical, is made.

The mortality rate of 12.5% may be considered high when compared to mortality rates (3.9% and 5.8%) from all causes of admission into the Children's emergency departments in the two study centers.[2],[10] This supports the fact that most of the childhood mortalities in our environment are due to infective causes which are largely preventable. Thus, policymakers and stakeholders in child health should devote their energies to infection prevention and control in the communities, as well as health education to improve care-seeking behaviors.


  Conclusion Top


Fever is a significant cause of mortality in the children emergency departments. Most of the factors responsible for the mortality in febrile children are largely preventable and treatable when the presentation is early.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
National Collaborating Centre for Women's and Children's Health (UK). Feverish Illness in Children: Assessment and Initial Management in Children Younger Than 5 Years. (NICE Clinical Guidelines, No. 160.). London: Royal College of Obstetricians & Gynaecologists (UK); 2013. p. 2. Available from: https://www.ncbi.nlm.nih.gov/books/NBK327857. [Last accessed on 2020 May 16].  Back to cited text no. 1
    
2.
Edelu BO, Eze JN, Oguonu T, Ndu IK. Morbidity and mortality pattern in the Children Emergency Unit of the University of Nigeria Teaching Hospital Enugu. Orient J Med 2014;26:73-8.  Back to cited text no. 2
    
3.
Bilkisu GI, Aminu MS, Sunday OO, Bassey E, Smart A, Muyideen AB. Pattern of medical childhood morbidity and mortality in a new specialist hospital in Gusau, Nigeria. Ann Niger Med 2014;8:15.  Back to cited text no. 3
    
4.
Powell KR. Fever. In: Behrman RE, Kliegman RM, Jenson HB, editors. Nelson Textbook of Pediatrics. 16th ed. Philadelphia: WB Saunders Company; 2000. p. 736-8.  Back to cited text no. 4
    
5.
Kluger MJ, Kozak W, Conn CA, Leon LR, Soszynski D. The adaptive value of fever. Infect Dis Clin North Am 1996;10:1-20.  Back to cited text no. 5
    
6.
Betz MG, Grunfeld AF. 'Fever phobia'in the emergency department: A survey of children's caregivers. Eur J Emerg Med 2006;13:129-33.  Back to cited text no. 6
    
7.
Poirier MP, Collins EP, McGuire E. Fever phobia: A survey of caregivers of children seen in a pediatric emergency department. Clin Pediatr (Phila) 2010;49:530-4.  Back to cited text no. 7
    
8.
Pondei K, Kunle-Olowu OE, Peterside O. The aetiology of non-malarial febrile illness in children in the malaria-endemic Niger Delta Region of Nigeria. Asian Pac J Trop Dis 2013;3:56-60.  Back to cited text no. 8
    
9.
Ndukwu CI, Onah SK. Pattern and outcome of postneonatal pediatric emergencies in Nnamdi Azikiwe University Teaching Hospital, Nnewi, South East Nigeria. Niger J Clin Pract 2015;18:348-53.  Back to cited text no. 9
[PUBMED]  [Full text]  
10.
Ndu IK, Uleanya ND, Nwokoye IC, Edelu BO, Asinobi IN, Ekwochi U, et al. Pattern of morbidity and mortality at the children emergency unit of Enugu state teaching hospital, Park lane, Enugu. J Exp Res 2016;4:48-54.  Back to cited text no. 10
    
11.
Ibeziako SN, Ibekwe RC. Pattern and outcome of admissions in the children's emergency room of the university of Nigeria teaching hospital, Enugu. Niger J Paediatr 2002;29:103-8.  Back to cited text no. 11
    
12.
Okposio MM, Unior MO, Ukpeteru FO. Socio-demographic determinants of mortality in hospitalized under-five children at a secondary health care centre in the Niger Delta. J Trop Dis Health 2012;2:173-81.  Back to cited text no. 12
    
13.
Budhathoki S, Poudel P, Shah D, Bhatta NK, Dutta AK, Shah GS, et al. Clinical profile and outcome of children presenting with poisoning or intoxication: A hospital based study. Nepal Med Coll J 2009;11:170-5.  Back to cited text no. 13
    
14.
Garnacho-Montero J, García-Cabrera E, Diaz-Martín A, Lepe-Jiménez JA, Iraurgi-Arcarazo P, Jiménez-Alvarez R, et al. Determinants of outcome in patients with bacteraemic pneumococcal pneumonia: Importance of early adequate treatment. Scand J Infect Dis 2010;42:185-92.  Back to cited text no. 14
    
15.
Okeke TA, Okeibunor JC. Rural-urban differences in health-seeking for the treatment of childhood malaria in South-East Nigeria. Health Policy 2010;95:62-8.  Back to cited text no. 15
    
16.
Piller S, Herzog D. The burden of visits for fever at a paediatric emergency room: A retrospective study on patients presenting at the cantons hospital of Fribourg, A peripheral public hospital of Switzerland. Pediatric Health Med Ther 2019;10:147-52.  Back to cited text no. 16
    
17.
Mackowiak PA, Wasserman SS, Levine MM. An analysis of the quantitative relationship between oral temperature and severity of illness in experimental shigellosis. J Infect Dis 1992;166:1181-4.  Back to cited text no. 17
    
18.
Mackowiak PA, Wasserman SS, Tacket CO, Vaughn DW, Eckels KH, Dubois DR, et al. Quantitative relationship between oral temperature and severity of illness following inoculation with candidate attenuated dengue virus vaccines. Clin Infect Dis 1994;19:948-50.  Back to cited text no. 18
    
19.
Brandts CH, Ndjavé M, Graninger W, Kremsner PG. Effect of paracetamol on parasite clearance time in Plasmodium falciparum malaria. Lancet 1997;350:704-9.  Back to cited text no. 19
    
20.
Newton CR, Warn PA, Winstanley PA, Peshu N, Snow RW, Pasvol G, et al. Severe anaemia in children living in a malaria endemic area of Kenya. Trop Med Int Health 1997;2:165-78.  Back to cited text no. 20
    
21.
English M, Ahmed M, Ngando C, Berkley J, Ross A. Blood transfusion for severe anaemia in children in a Kenyan hospital. Lancet 2002;359:494-5.  Back to cited text no. 21
    
22.
World Health Organization. Department of Child, Adolescent Health, World Health Organization, UNICEF. Handbook IMCI: Integrated Management of Childhood Illness. World Health Organization; 2005.  Back to cited text no. 22
    



 
 
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  [Table 1], [Table 2], [Table 3], [Table 4]



 

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